|By Business Wire||
|July 28, 2014 09:57 AM EDT||
A group of researchers in Taiwan has developed a new optical technology that may be able to detect an early complication of diabetes sooner, when it is more easily treated. If the device proves safe and effective in clinical trials, it may pave the way for the early detection and more effective treatment of this complication, called diabetic autonomic neuropathy, which is common among people with both Type 1 and Type 2 diabetes. The condition progressively affects the autonomic nerves controlling vital organs like the heart and gastrointestinal system. This can lead to problems like fainting, incontinence, nausea, heart arrhythmias and an increased risk of bacterial infection.
A prototype pupillometer designed for a patient to wear for a half hour or so in a doctor's office and test for diabetic autonomic neuropathy. It may help diagnose the condition sooner, leading to better treatment outcomes. Credit: M. Ou-Yang, National Chiao-Tung University, Taiwan.
Described in a paper published today in The Optical Society (OSA)’s journal Applied Optics, the new technology is a small, wearable device called a pupillometer that can hang on a pair of eyeglasses and only weighs 78 grams, slightly heavier than Google Glass. Developed by a team at National Taiwan University Hospital, Hsin Chu branch and National Chiao-Tung University, the device is designed to be worn for a half hour or so in the doctor's office, during which time it would monitor a person's pupils. By carefully measuring five parameters associated with the pupils, doctors may then be able to detect the earliest signs of diabetic autonomic neuropathy.
Detecting someone's asymptomatic diabetic autonomic neuropathy early and treating it properly may lead to far better health outcomes for them. Currently the condition is often not detected until moderate nerve damage and organ dysfunction are present.
Currently doctors rely on observing changes in digestive speed, heart rate and blood pressure to detect diabetic autonomic neuropathy, but this limits their ability to make a diagnosis early on, said Mang Ou-Yang, who led the research with colleagues at National Chiao-Tung University. Now they have shown that monitoring the pupils of people with diabetes may be a better approach.
"Compared to the existing diagnostic techniques, the pupillometer is a more reliable, effective, portable and inexpensive solution for diagnosing diabetic autonomic neuropathy in its early stages," said Ou-Yang.
The pupil is useful for detecting diabetic autonomic neuropathy due to the neurological conditions caused by the disease. Like many organs, the eyes and pupil are dually innervated, receiving signals from both the parasympathetic and sympathetic divisions of the autonomic nervous system. These divisions control the pupil’s circular and radial muscles, respectively.
The pupillometer, which is small enough to be mounted onto the front of a pair of glasses, works by emitting four colored lights to stimulate the pupil. A beam splitter attached to the device then filters the visible light that is reflected from the eye to the device’s camera, which processes the images to analyze the pupil’s size.
The device measures 10 parameters related to pupil diameter and response time. Of those 10, the researchers found that five parameters were significantly different in people with diabetic autonomic neuropathy.
Ou-Yang says if clinical trials are successful, the pupillometer could be available by the end of the decade.
Future research for Ou-Yang and his lab includes scaling down the size of the device, expanding the device’s capabilities to observe two pupils simultaneously and collecting more experimental results from diabetic patients.
Paper: “Design and analysis of wearable pupillometer for autonomic neuropathy of diabetic patients,” M.-L. Ko et al., Applied Optics, Volume 53, Issue 29, pp. H27-H34 (2014).
EDITOR’S NOTE: Images are available to members of the media upon request. Contact Angela Stark, [email protected] or 202.416.1443.
About Applied Optics
Applied Optics publishes articles emphasizing applications-centered research in optics, moving the potential of science and technology to the practical. Published three times each month, Applied Optics reports significant optics applications from optical testing and instrumentation to medical optics...from holography to optical neural networks...from LIDAR and remote sensing to laser materials processing. Each issue contains content from three divisions of editorial scope: Optical Technology; Information Processing; and Lasers, Photonics and Environmental Optics. It is edited by Joseph Mait of the U.S. Army Research Laboratory. For more information, visit www.OpticsInfoBase.org/AO.
Founded in 1916, The Optical Society (OSA) is the leading professional society for scientists, engineers, students and business leaders who fuel discoveries, shape real-world applications and accelerate achievements in the science of light. Through world-renowned publications, meetings and membership programs, OSA provides quality research, inspired interactions and dedicated resources for its extensive global network of professionals in optics and photonics. For more information, visit www.osa.org.
SYS-CON Events announced today that Bsquare has been named “Silver Sponsor” of SYS-CON's @ThingsExpo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. For more than two decades, Bsquare has helped its customers extract business value from a broad array of physical assets by making them intelligent, connecting them, and using the data they generate to optimize business processes.
Oct. 1, 2016 03:00 PM EDT Reads: 3,046
In this strange new world where more and more power is drawn from business technology, companies are effectively straddling two paths on the road to innovation and transformation into digital enterprises. The first path is the heritage trail – with “legacy” technology forming the background. Here, extant technologies are transformed by core IT teams to provide more API-driven approaches. Legacy systems can restrict companies that are transitioning into digital enterprises. To truly become a lea...
Oct. 1, 2016 01:30 PM EDT Reads: 866
Internet of @ThingsExpo, taking place November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with 19th Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world. The Internet of Things (IoT) is the most profound change in personal and enterprise IT since the creation of the Worldwide Web more than 20 years ago. All major researchers estimate there will be tens of billions devices - comp...
Oct. 1, 2016 01:00 PM EDT Reads: 5,188
Just over a week ago I received a long and loud sustained applause for a presentation I delivered at this year’s Cloud Expo in Santa Clara. I was extremely pleased with the turnout and had some very good conversations with many of the attendees. Over the next few days I had many more meaningful conversations and was not only happy with the results but also learned a few new things. Here is everything I learned in those three days distilled into three short points.
Oct. 1, 2016 12:30 PM EDT Reads: 5,540
“We're a global managed hosting provider. Our core customer set is a U.S.-based customer that is looking to go global,” explained Adam Rogers, Managing Director at ANEXIA, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Oct. 1, 2016 12:30 PM EDT Reads: 3,272
Why do your mobile transformations need to happen today? Mobile is the strategy that enterprise transformation centers on to drive customer engagement. In his general session at @ThingsExpo, Roger Woods, Director, Mobile Product & Strategy – Adobe Marketing Cloud, covered key IoT and mobile trends that are forcing mobile transformation, key components of a solid mobile strategy and explored how brands are effectively driving mobile change throughout the enterprise.
Oct. 1, 2016 12:30 PM EDT Reads: 2,340
What are the new priorities for the connected business? First: businesses need to think differently about the types of connections they will need to make – these span well beyond the traditional app to app into more modern forms of integration including SaaS integrations, mobile integrations, APIs, device integration and Big Data integration. It’s important these are unified together vs. doing them all piecemeal. Second, these types of connections need to be simple to design, adapt and configure...
Oct. 1, 2016 12:30 PM EDT Reads: 650
Adobe is changing the world though digital experiences. Adobe helps customers develop and deliver high-impact experiences that differentiate brands, build loyalty, and drive revenue across every screen, including smartphones, computers, tablets and TVs. Adobe content solutions are used daily by millions of companies worldwide-from publishers and broadcasters, to enterprises, marketing agencies and household-name brands. Building on its established design leadership, Adobe enables customers not o...
Oct. 1, 2016 12:30 PM EDT Reads: 645
SYS-CON Events announced today the Enterprise IoT Bootcamp, being held November 1-2, 2016, in conjunction with 19th Cloud Expo | @ThingsExpo at the Santa Clara Convention Center in Santa Clara, CA. Combined with real-world scenarios and use cases, the Enterprise IoT Bootcamp is not just based on presentations but with hands-on demos and detailed walkthroughs. We will introduce you to a variety of real world use cases prototyped using Arduino, Raspberry Pi, BeagleBone, Spark, and Intel Edison. Y...
Oct. 1, 2016 12:30 PM EDT Reads: 3,113
Ask someone to architect an Internet of Things (IoT) solution and you are guaranteed to see a reference to the cloud. This would lead you to believe that IoT requires the cloud to exist. However, there are many IoT use cases where the cloud is not feasible or desirable. In his session at @ThingsExpo, Dave McCarthy, Director of Products at Bsquare Corporation, will discuss the strategies that exist to extend intelligence directly to IoT devices and sensors, freeing them from the constraints of ...
Oct. 1, 2016 11:45 AM EDT Reads: 2,813
SYS-CON Events announced today that Sheng Liang to Keynote at SYS-CON's 19th Cloud Expo, which will take place on November 1-3, 2016 at the Santa Clara Convention Center in Santa Clara, California.
Oct. 1, 2016 11:45 AM EDT Reads: 322
Technology vendors and analysts are eager to paint a rosy picture of how wonderful IoT is and why your deployment will be great with the use of their products and services. While it is easy to showcase successful IoT solutions, identifying IoT systems that missed the mark or failed can often provide more in the way of key lessons learned. In his session at @ThingsExpo, Peter Vanderminden, Principal Industry Analyst for IoT & Digital Supply Chain to Flatiron Strategies, will focus on how IoT de...
Oct. 1, 2016 11:30 AM EDT Reads: 1,336
Complete Internet of Things (IoT) embedded device security is not just about the device but involves the entire product’s identity, data and control integrity, and services traversing the cloud. A device can no longer be looked at as an island; it is a part of a system. In fact, given the cross-domain interactions enabled by IoT it could be a part of many systems. Also, depending on where the device is deployed, for example, in the office building versus a factory floor or oil field, security ha...
Oct. 1, 2016 11:15 AM EDT Reads: 889
24Notion is full-service global creative digital marketing, technology and lifestyle agency that combines strategic ideas with customized tactical execution. With a broad understand of the art of traditional marketing, new media, communications and social influence, 24Notion uniquely understands how to connect your brand strategy with the right consumer. 24Notion ranked #12 on Corporate Social Responsibility - Book of List.
Oct. 1, 2016 10:45 AM EDT Reads: 641
Fact is, enterprises have significant legacy voice infrastructure that’s costly to replace with pure IP solutions. How can we bring this analog infrastructure into our shiny new cloud applications? There are proven methods to bind both legacy voice applications and traditional PSTN audio into cloud-based applications and services at a carrier scale. Some of the most successful implementations leverage WebRTC, WebSockets, SIP and other open source technologies. In his session at @ThingsExpo, Da...
Oct. 1, 2016 10:30 AM EDT Reads: 1,734
Businesses are struggling to manage the information flow and interactions between all of these new devices and things jumping on their network, and the apps and IT systems they control. The data businesses gather is only helpful if they can do something with it. In his session at @ThingsExpo, Chris Witeck, Principal Technology Strategist at Citrix, will discuss how different the impact of IoT will be for large businesses, expanding how IoT will allow large organizations to make their legacy ap...
Oct. 1, 2016 10:30 AM EDT Reads: 729
What happens when the different parts of a vehicle become smarter than the vehicle itself? As we move toward the era of smart everything, hundreds of entities in a vehicle that communicate with each other, the vehicle and external systems create a need for identity orchestration so that all entities work as a conglomerate. Much like an orchestra without a conductor, without the ability to secure, control, and connect the link between a vehicle’s head unit, devices, and systems and to manage the ...
Oct. 1, 2016 10:00 AM EDT Reads: 536
What does it look like when you have access to cloud infrastructure and platform under the same roof? Let’s talk about the different layers of Technology as a Service: who cares, what runs where, and how does it all fit together. In his session at 18th Cloud Expo, Phil Jackson, Lead Technology Evangelist at SoftLayer, an IBM company, spoke about the picture being painted by IBM Cloud and how the tools being crafted can help fill the gaps in your IT infrastructure.
Oct. 1, 2016 10:00 AM EDT Reads: 3,218
For basic one-to-one voice or video calling solutions, WebRTC has proven to be a very powerful technology. Although WebRTC’s core functionality is to provide secure, real-time p2p media streaming, leveraging native platform features and server-side components brings up new communication capabilities for web and native mobile applications, allowing for advanced multi-user use cases such as video broadcasting, conferencing, and media recording.
Oct. 1, 2016 10:00 AM EDT Reads: 3,334
In his session at @ThingsExpo, Kausik Sridharabalan, founder and CTO of Pulzze Systems, Inc., will focus on key challenges in building an Internet of Things solution infrastructure. He will shed light on efficient ways of defining interactions within IoT solutions, leading to cost and time reduction. He will also introduce ways to handle data and how one can develop IoT solutions that are lean, flexible and configurable, thus making IoT infrastructure agile and scalable.
Oct. 1, 2016 09:15 AM EDT Reads: 1,690